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Photodynamic therapy (PDT) is a treatment used for
nonmelanoma skin cancer. PDT is a process of applying
a medicine and then shining a special light on it. It may be used to treat skin cancers when surgery or radiation can't be used.
Medicines used in PDT for skin cancer include 5-aminolevulinic acid (ALA), methyl aminolevulinate (MAL), and porfirmer sodium.
PDT is used to treat
actinic keratoses on the face and scalp,
squamous cell carcinoma in situ (Bowen's disease), and superficial
basal cell carcinomas. Studies show that cure rates for skin cancers treated with PDT may be slightly lower than surgery or radiation. But PDT does not leave a scar like surgery does.1
Studies of PDT with methyl aminolevulinate (MAL) found that this treatment was as effective as cryosurgery for actinic keratoses and squamous cell carcinoma in situ (Bowen's disease).2
National Comprehensive Cancer Network (2012). Basal cell and squamous cell skin cancers. NCCN Clinical Practice Guidelines in Oncology, Version 2. Available online: http://www.nccn.org/professionals/physician_gls/PDF/nmsc.pdf.
National Comprehensive Cancer Network (2010). Basal cell and squamous cell skin cancers. NCCN Clinical Practice Guidelines in Oncology, Version 1. Available online: http://www.nccn.org/professionals/physician_gls/PDF/nmsc.pdf.
September 17, 2013
E. Gregory Thompson, MD - Internal Medicine & Amy McMichael, MD - Dermatology
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