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Natalie D. Depcik-Smith

Natalie D. Depcik-Smith, MD

Specialties and/or Subspecialties

  • Pathology,
  • Dermatopathology
  • Melanoma (Skin)


Dermatopathologist Natalie Depcik-Smith, MD, serves as the medical director for the multi-disciplinary melanoma/sarcoma program at the Cone Health Cancer Center. She is also the laboratory director for ADX GPA Laboratories in Greensboro.

Affiliated with Cone Health since 2004, she values the community sense of belonging, multi-disciplinary and collaborative approach to patient care, the strength of cancer care programs and the expertise of the physicians with whom she collaborates. 

A native of Chicago, Dr. Depcik-Smith and her husband enjoy the climate and people of North Carolina. She is fluent in French, a two-time Chicago marathon finisher and enjoys traveling with her husband. Also, her two Cavalier King Charles Spaniels are a source of immense joy.

“The affinity I have for the leaders and participants in the programs we integrate as part of the comprehensive cancer care that Cone Health offers are a source of great inspiration, and I hope to continue in this regard for some time into the future.” – Natalie Depcik-Smith, MD



Medical School

Vanderbilt University Medical School


UNC Chapel Hill School of Public Health, Pathology


University of Florida, Dermatopathology

Board Certifications

  • Anatomic Pathology & Clinical Pathology
  • Dermatopathology