Setting your location helps us to show you nearby providers and locations based on your healthcare needs.
Your Location is set to Change My Location
Cone Health wants to help you get well and stay well. This section provides tools and information to achieve good health and maintain your well-being.
Learn what community resources are available to help you get well and stay well.
View health and wellness news you can use from Cone Health providers on
View Advanced Search OptionsView All Doctors
View All Locations
Home > Patient & Family Resources > Health Library > Radioactive Iodine for Hyperthyroidism
Committed to Safety: As we resume services, we are taking all necessary precautions to keep you safe while we care for you. Please note that visitor restrictions remain in place. Get more information on COVID-19.
Radioactive iodine is a medicine that you take one time. After you swallow it, it is taken up by your thyroid gland. Depending on the dosage used, the radioactivity in the iodine destroys most or all of the tissue in your thyroid gland, but it does not harm any other parts of your body.
While radiation can cause thyroid cancer, treatment of hyperthyroidism with radioactive iodine does not increase your chances of getting thyroid cancer.
Radioactive iodine treatment has been safely used on millions of people for more than 60 years.
Most people don't feel different after treatment. But a few people may have nausea.
Within a few days after treatment, the radioactive iodine will leave your body in your urine and saliva. How long it takes will depend on your age and on the dose you received. Young people get rid of radioactive iodine faster than older adults. Drink plenty of fluids during this time to help your body get rid of the radioactivity.
Your doctor will give you written instructions. To avoid exposing other people to radioactivity, it is important to follow your doctor's instructions carefully. He or she will instruct you on how far to stay away from people, how long you need to sleep alone, and other ways to stay safe. You will be directed to avoid close contact, kissing, sex, and sharing cups, dishes, or utensils.
Some general recommendations include:footnote 1
After you take your treatment, you may have follow-up exams every 4 to 6 weeks until your thyroid hormone levels return to normal.
Radioactive iodine has the best chance of permanently curing hyperthyroidism. Doctors often use it if your hyperthyroidism comes back after you have been treated with antithyroid medicine. It can also be used if your hyperthyroidism comes back after you have surgery to remove part of your thyroid gland.
For most people, one dose of radioactive iodine treatment will cure hyperthyroidism. Usually, thyroid hormone levels return to normal in 8 to 12 weeks. In rare cases, the person needs a second or third dose of radioactive iodine.
Some side effects from radioactive iodine treatment include:
If you have Graves' ophthalmopathy, it may get worse temporarily after radioactive iodine therapy.
Most people—depending on their ages, how much thyroid hormone their bodies make, and other health conditions they have—are treated first with radioactive iodine.
Radioactive iodine is often recommended if you have Graves' disease and are older than 50, or if you have thyroid nodules (toxic multinodular goiter) that are releasing too much thyroid hormone. Radioactive iodine is not used if:
You may take antithyroid medicine for several weeks or months before treatment with radioactive iodine. The antithyroid medicine will lower thyroid hormone levels in your body and will also lower your chances of having a more serious problem called thyroid storm. You may also take additional medicines that can make you feel better and help your thyroid return to normal before you are given radioactive iodine.
Radioactive iodine has been used to treat hyperthyroidism for more than 60 years. There is no evidence that radioactive iodine causes cancer, infertility, or birth defects.
If you have had radioactive iodine treatment and you want to travel within a few days after treatment, prepare for any problems you may have at airport security. People who have had radioactive iodine treatment can set off the radiation detection machines in airports.
If you plan to travel within 5 to 7 days of your radioactive treatment:
Sisson JC, et al. (2011). Radiation safety in the treatment of patients with thyroid diseases by radioiodine 131I: Practice recommendations of the American Thyroid Association. From the American Thyroid Association Taskforce on Radioiodine Safety. Thyroid, 21(4): 335–346.
Current as of:
July 29, 2019
Author: Healthwise StaffMedical Review: E. Gregory Thompson MD - Internal MedicineKathleen Romito MD - Family MedicineDavid C.W. Lau MD, PhD, FRCPC - Endocrinology
Current as of: July 29, 2019
Author: Healthwise Staff
Medical Review:E. Gregory Thompson MD - Internal Medicine & Kathleen Romito MD - Family Medicine & David C.W. Lau MD, PhD, FRCPC - Endocrinology
To learn more about Healthwise, visit Healthwise.org.
© 1995-2020 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Subscribe to our Wellness Matters e-newsletter, a monthly snapshot of the some of great wellness content from Cone Health providers.