Setting your location helps us to show you nearby providers and locations based on your healthcare needs.
Your Location is set to Change My Location
Cone Health wants to help you get well and stay well. This section provides tools and information to achieve good health and maintain your well-being.
Learn what community resources are available to help you get well and stay well.
View health and wellness news you can use from Cone Health providers on
View Advanced Search OptionsView All Doctors
View All Locations
Home > Patient & Family Resources > Health Library > Mononucleosis Complications
COVID-19 Info: Current Trends | Vaccine Scheduling | Visitor Guidelines | COVID-19 Testing | More
IMPORTANT NOTICE: Please do not use Cone Health emergency departments or urgent care centers for Covid-19 testing to avoid long wait times and enable clinical teams to focus on critical care needs. Get options for testing here.
Most people recover from mononucleosis (mono) without any complications. But there are many possible complications of mono. These include:
Other complications of mono can occur but are very rare. These include:
While it is not a complication specific to mono, a serious disease known as Reye syndrome can develop if you give aspirin to a person younger than 20 to treat symptoms of mono. Aspirin should not be used to treat symptoms of mono. Other medicines, such as acetaminophen (for example, Tylenol) or ibuprofen (for example, Advil) can help relieve fever and pain caused by mono. Be safe with medicines. Read and follow all instructions on the label.
Even if you have a complication of mono, it is likely that you will recover completely.
Levin MJ, Weinberg A (2012). Infections: Viral and rickettsial. In WW Hay Jr et al., eds., Current Diagnosis and Treatment: Pediatrics, 21st ed., pp. 1177–1219. New York: McGraw-Hill.
American Academy of Pediatrics (2012). Epstein-Barr virus infections (infectious mononucleosis). In LK Pickering et al., eds., Red Book: 2012 Report of the Committee on Infectious Diseases, 29th ed., pp. 318–321. Elk Grove Village, IL: American Academy of Pediatrics.
Other Works Consulted
Levin M, et al. (2014). Infections: Viral and rickettsial. In WW Hay Jr et al., eds., Current Diagnosis and Treatment: Pediatrics, 22nd ed., pp. 1227–1270. New York: McGraw-Hill.
Current as of: March 17, 2021
Author: Healthwise StaffMedical Review: E. Gregory Thompson MD - Internal MedicineJohn Pope MD - PediatricsAdam Husney MD - Family MedicineCaroline S. Rhoads MD - Internal Medicine
Current as of: March 17, 2021
Author: Healthwise Staff
Medical Review:E. Gregory Thompson MD - Internal Medicine & John Pope MD - Pediatrics & Adam Husney MD - Family Medicine & Caroline S. Rhoads MD - Internal Medicine
To learn more about Healthwise, visit Healthwise.org.
© 1995-2021 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Subscribe to our Wellness Matters e-newsletter, a monthly snapshot of the some of great wellness content from Cone Health providers.